Sihem Boudina

Endocrinology & Metabolism (Internal Medicine)
Research Assistant Professor

Research Interests

Dr. Boudina's laboratory studies cardiac bioenergetics in health and disease. Long-term interests include defining the role of insulin signaling on mammalian cardiac aging with specific focus on the role of insulin signaling-modulation of autophagy and how that affects cardiac aging.

Recent Publications

1- O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S,

Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED. (2007). A conserved role for phosphatidylinositol 3-kinase

but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab, 6(4), 294-306.

Cited in PubMed Central; PMC2084219.

2- Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R.

(2007). CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial

ischemia in aging mice. Am J Physiol Heart Circ Physiol, 293(5), H3201-9.

3- Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H,

Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. (2009). Contribution

of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation (online), 119(9),

1272-83.

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