Noel Carlson
- Department of Neurobiology and Anatomy
- GRECC Investigator
Research Interests
My research interests center on understanding how inflammatory mediators contribute to age-related neurodegenerative disease. Our work has concentrated on how the enzyme Cyclooxygenase-2 (COX-2) contributes to injury of neurons and oligodendrocytes (the myelin-producing cells in the CNS). An understanding of how COX-2 contributes to the pathophysiology of neurodegenerative diseases could lead to new therapeutic approaches to preventing or treating diseases of the central nervous system.
Recent Publications:
Carlson N.G., K.E. Hill, I Tsunoda, R.S. Fujinami, J.W. Rose. 2006. The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. Journal of Neuroimmunology 174(1-2):21-31.
Carlson N.G. and J.W. Rose. 2006. Antioxidants in multiple sclerosis: Do they have a role? CNS Drugs 20(6):433-441
Rose, J.W., K.E. Hill, H. Watt and N.G. Carlson. 2004. Inflammatory Cell Expression of Cyclooxygenase-2 (COX-2) in the MS Lesion. Journal of Neuroimmunology 149:40-49.
Carlson N.G., 2003. “Neuroprotection mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid” Journal of Neurosci. Res 71:79-88.
